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Description:

Cholecalciferol, generally known as vitamin D3 (VD), and calcium (Ca2+) are very common dietary co-supplements in the pharmaceutical formulations, as they are symbiotically and pharmacologically dependent. Development of the VD/Ca2+ formulation is highly challenging due to stability and solubility issues, mainly for VD instability toward temperature, light, oxygen and pH. In this study, VD was loaded into carrier which consisted of amorphous calcium carbonate (ACC) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), yielding amorphous VD/ACC/HPMCAS formulation with various composition ratios.

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• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

  © 2024.
  Licensed under the Creative Commons https://creativecommons.org/licenses/by-nc-nd/4.0/.

Keyword: cholecalciferol, amorphous calcium carbonate, thermal stability, isoconversional kinetics

Date published: 2024-03-30

Publisher: Elsevier BV

Journal:

• Thermochimica Acta (ISSN: 00406031) vol. 736 179740

Funding:

• Matsumae International Foundation 23G05
• Ministry of Scientific and Technological Development, Higher Education and Information Society 19.032/961-96/23

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4675

First published URL: https://doi.org/10.1016/j.tca.2024.179740

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Updated at: 2026-03-31 08:30:04 +0900

Published on MDR: 2026-03-31 08:15:42 +0900