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説明:

Cholecalciferol, generally known as vitamin D3 (VD), and calcium (Ca2+) are very common dietary co-supplements in the pharmaceutical formulations, as they are symbiotically and pharmacologically dependent. Development of the VD/Ca2+ formulation is highly challenging due to stability and solubility issues, mainly for VD instability toward temperature, light, oxygen and pH. In this study, VD was loaded into carrier which consisted of amorphous calcium carbonate (ACC) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), yielding amorphous VD/ACC/HPMCAS formulation with various composition ratios.

権利情報:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

  © 2024.
  Licensed under the Creative Commons https://creativecommons.org/licenses/by-nc-nd/4.0/.

キーワード: cholecalciferol, amorphous calcium carbonate, thermal stability, isoconversional kinetics

刊行年月日: 2024-03-30

出版者: Elsevier BV

掲載誌:

• Thermochimica Acta (ISSN: 00406031) vol. 736 179740

研究助成金:

• Matsumae International Foundation 23G05
• Ministry of Scientific and Technological Development, Higher Education and Information Society 19.032/961-96/23

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4675

公開URL: https://doi.org/10.1016/j.tca.2024.179740

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更新時刻: 2026-03-31 08:30:04 +0900

MDRでの公開時刻: 2026-03-31 08:15:42 +0900