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Clathrin protein coats the deposits into vesicles, sorts and carries the cargo to the destination, thus, cleans the waste. The degraded product of the amyloid precursor protein Aβ and its aggregated fibrils are associated with Alzheimer’s disease. Why Clathrin fails to arrest the rapid aggregation is debated. Here, we demonstrate that in contact with a hexagonal-close-packed organic substrate, the Aβ(1-42) fibrils form an electromagnetically responsive fractal superstructure. Using two independent experimental techniques with microwave and laser spectroscopy, we have discovered the electric pulse generating ability (i.e., beating/interference) of the Aβ-fractal networks that fine-tune the Clathrin-mediated disassembly by inducing step-by-step morphogenesis. A fractal antenna network has multiple communication modes; beating is essential to disassemble it. Rapid multi-scale synthesis of antenna-network only in the presence of a typical geometric shape is unprecedented. Our finding sheds light on how brain deposits could suddenly outsmart the natural brain cleansing and how we could bypass the rapid propagation of Alzheimer’s.

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• In Copyright
  

Keyword: Alzheimer, Clathrin, beta plaque, neurological disorder

Date published: 2023-06-28

Publisher: Springer Nature Singapore

Journal:

• Lecture Notes in Networks and Systems (ISSN: 23673370) p. 323-344

Funding:

Manuscript type: Author's version (Submitted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5271

First published URL: https://doi.org/10.1007/978-981-99-1916-1_25

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Updated at: 2025-01-15 16:31:32 +0900

Published on MDR: 2025-01-15 16:31:33 +0900