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The stabilization mechanism of mesoporous silica (MS) of two different pore sizes (21 and 2.5 nm) on overloaded celecoxib (CEL) glass was investigated. Differential scanning calorimetry (DSC) measurements revealed the presence of three fractions with different molecular mobilities: free, intermediate, and rigid ones. The free fraction exhibited cold crystallization during DSC heating and was assumed to have almost the same properties as those of the bulk molecules. The rigid fraction did not exhibit either glass transition or cold crystallization behavior, which should be stabilized by interactions with the MS surface. The remaining molecules exhibited glass transition behavior without any tendency toward cold crystallization during heating, which is called the intermediate fraction. The molecular dynamics of each fraction was investigated by using broadband dielectric spectroscopy (BDS).

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: glass, mesoporous silica, crystallization, cooperatively rearranging region, broadband dielectric spectroscopy, differential scanning calorimetry

刊行年月日: 2025-05-05

出版者: American Chemical Society (ACS)

掲載誌:

• Molecular Pharmaceutics (ISSN: 15438392) vol. 22 issue. 5 p. 2556-2567

研究助成金:

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1021/acs.molpharmaceut.4c01482

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更新時刻: 2025-11-10 12:30:15 +0900

MDRでの公開時刻: 2025-11-10 12:24:34 +0900