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The stabilization mechanism of mesoporous silica (MS) of two different pore sizes (21 and 2.5 nm) on overloaded celecoxib (CEL) glass was investigated. Differential scanning calorimetry (DSC) measurements revealed the presence of three fractions with different molecular mobilities: free, intermediate, and rigid ones. The free fraction exhibited cold crystallization during DSC heating and was assumed to have almost the same properties as those of the bulk molecules. The rigid fraction did not exhibit either glass transition or cold crystallization behavior, which should be stabilized by interactions with the MS surface. The remaining molecules exhibited glass transition behavior without any tendency toward cold crystallization during heating, which is called the intermediate fraction. The molecular dynamics of each fraction was investigated by using broadband dielectric spectroscopy (BDS).

Rights:

• Creative Commons BY Attribution 4.0 International
  

Keyword: glass, mesoporous silica, crystallization, cooperatively rearranging region, broadband dielectric spectroscopy, differential scanning calorimetry

Date published: 2025-05-05

Publisher: American Chemical Society (ACS)

Journal:

• Molecular Pharmaceutics (ISSN: 15438392) vol. 22 issue. 5 p. 2556-2567

Funding:

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1021/acs.molpharmaceut.4c01482

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Updated at: 2025-11-10 12:30:15 +0900

Published on MDR: 2025-11-10 12:24:34 +0900