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説明:

Human microbiota, akin to human cells releasing exosomes, produce spherical biological nanoparticles, bacterial extracellular vesicles (BEVs). These BEVs are composed of lipid bilayers and encapsulate a variety of biological molecules from their source cells such as signaling molecules, genetic materials, and proteins. BEVs have been known to contribute to diverse biological processes in the human body by mediating both microbe-microbe and host-microbe interactions (Schwechheimer and Kuehn 2015; Cuesta et al. 2021). Yet, while the importance of their cargo is well-recognized, the question remains: do bacteria actively biosynthesize the BEVs to control their cargo on purpose?
Recent studies have been demonstrated that BEVs are not just the by-products of cell-lysis or imbalance in local cell membrane properties but produced via various types of regulations (Fig. 1)(Schwechheimer and Kuehn 2015). Genetic alterations can either enhance or inhibit the formation of BEVs (Kitagawa et al. 2010; Kulp et al. 2015), and evidence points to the selective, rather than random, packaging of certain molecules like proteins and lipids within BEVs (Schwechheimer and Kuehn 2015; Bonnington and Kuehn 2016; Orench-Rivera and Kuehn 2021; Naradasu et al. 2021).

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キーワード: bacterial membrane vesicle, single-particle analysis, microbiome, nanowire

刊行年月日: 2025-02-28

出版者: Springer Singapore

掲載誌:

• Extracellular Fine Particles

研究助成金:

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.6143

公開URL: https://doi.org/10.1007/978-981-97-7067-0_9

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更新時刻: 2026-01-19 10:38:01 +0900

MDRでの公開時刻: 2026-01-19 12:21:50 +0900