Bioactive Alkaloids from Nepalese <i>Corydalis chaerophylla</i> D.C. Acting on the Regulation of PCSK9 and LDL‐R <i>In Vitro</i>

Binita Maharjan; Ilaria Rossi; Stefania Sut; Timila Shrestha; Lok Kumar Shrestha; Jonathan P. Hill; Katsuhiko Ariga; Veronica Benetazzo; Maria Pia Adorni; Bianca Papotti; Shyam Sharan Shrestha; Ram Lal Swagat Shrestha; Nicola Ferri; Stefano Dall'Acqua

doi:10.1002/cbdv.202401388

論文 Bioactive Alkaloids from Nepalese Corydalis chaerophylla D.C. Acting on the Regulation of PCSK9 and LDL‐R In Vitro

Binita Maharjan ; Ilaria Rossi ; Stefania Sut ; Timila Shrestha ; Lok Kumar Shrestha (National Institute for Materials Science) ; Jonathan P. Hill (National Institute for Materials Science) ; Katsuhiko Ariga (National Institute for Materials Science) ; Veronica Benetazzo ; Maria Pia Adorni ; Bianca Papotti ; Shyam Sharan Shrestha ; Ram Lal Swagat Shrestha ; Nicola Ferri ; Stefano Dall'Acqua

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Binita Maharjan, Ilaria Rossi, Stefania Sut, Timila Shrestha, Lok Kumar Shrestha, Jonathan P. Hill, Katsuhiko Ariga, Veronica Benetazzo, Maria Pia Adorni, Bianca Papotti, Shyam Sharan Shrestha, Ram Lal Swagat Shrestha, Nicola Ferri, Stefano Dall'Acqua. Bioactive Alkaloids from Nepalese Corydalis chaerophylla D.C. Acting on the Regulation of PCSK9 and LDL‐R In Vitro. Chemistry & Biodiversity. 2024, 21 (12), e202401388. https://doi.org/10.1002/cbdv.202401388

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(abstract)

The new alkaloids were tested in human hepatoma cell line to assess their ability to modulate the expression of low-density lipoprotein receptor (LDL-R), of proprotein convertase subtilisin/kexin 9 (PCSK9) and to affect cellular cholesterol biosynthesis with the aim to evaluate their potential hypocholesterolemic effect.

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