Journal article Bioactive Alkaloids from Nepalese Corydalis chaerophylla D.C. Acting on the Regulation of PCSK9 and LDL‐R In Vitro
Binita Maharjan (author) (Search by this author)
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Ilaria Rossi (author) (Search by this author)
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Stefania Sut (author) (Search by this author)
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Timila Shrestha (author) (Search by this author)
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Lok Kumar Shrestha (author) (Search by this author)
ORCID https://orcid.org/0000-0003-2680-6291
National Institute for Materials Science
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Jonathan P. Hill (author) (Search by this author)
ORCID https://orcid.org/0000-0002-4229-5842
National Institute for Materials Science
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Katsuhiko Ariga (author) (Search by this author)
ORCID https://orcid.org/0000-0002-2445-2955
National Institute for Materials Science
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Veronica Benetazzo (author) (Search by this author)
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Maria Pia Adorni (author) (Search by this author)
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Bianca Papotti (author) (Search by this author)
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Shyam Sharan Shrestha (author) (Search by this author)
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Ram Lal Swagat Shrestha (author) (Search by this author)
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Nicola Ferri (author) (Search by this author)
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Stefano Dall'Acqua (author) (Search by this author)
ChemBiodiversity24_ 21_e20240138.pdf
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Binita Maharjan, Ilaria Rossi, Stefania Sut, Timila Shrestha, Lok Kumar Shrestha, Jonathan P. Hill, Katsuhiko Ariga, Veronica Benetazzo, Maria Pia Adorni, Bianca Papotti, Shyam Sharan Shrestha, Ram Lal Swagat Shrestha, Nicola Ferri, Stefano Dall'Acqua. Bioactive Alkaloids from Nepalese Corydalis chaerophylla D.C. Acting on the Regulation of PCSK9 and LDL‐R In Vitro. Chemistry & Biodiversity. 2024, 21 (12), e202401388. https://doi.org/10.1002/cbdv.202401388
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(abstract)

The new alkaloids were tested in human hepatoma cell line to assess their ability to modulate the expression of low-density lipoprotein receptor (LDL-R), of proprotein convertase subtilisin/kexin 9 (PCSK9) and to affect cellular cholesterol biosynthesis with the aim to evaluate their potential hypocholesterolemic effect.

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Keyword: Isoquinoline alkaloids, Corydalis chaerophylla D.C., PCSK9, LDL- R

Date published: 2024-10-28

Publisher: Wiley

Journal:

  • Chemistry & Biodiversity (ISSN: 16121872) vol. 21 issue. 12 e202401388

Funding:

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1002/cbdv.202401388

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Updated at: 2024-12-18 16:30:36 +0900

Published on MDR: 2024-12-19 08:30:37 +0900

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