Download all files (2.01 MB)

Collection

Citation

Description:

Metasurfaces exhibit excellent optical performance to enhance the light–matter interaction of target molecules in biosensing based on its well-optimized nanostructured unit cells. In the meantime, fluorescence (FL) biosensors with aggregation induced emissions (AIE) features also demonstrate outstanding performance in biomarker detection due to its fast response, high selectivity, and low background noise. Nevertheless, extremely low-level analytes are difficult to detect in practical applications since complex urine samples include a number of uncontrolled variables such as impurities, autofluorescence, other urine components, etc. At present, improving photosignal sensitivity of human serum albumin (HSA) detection is always a big challenge to overcome such interference in human urine scenarios. In this work, we have first combined an AIE-based fluorescent FL biosensor TPE-4TA with an all-dielectric metasurface platform to achieve quantitative detection of trace HSA in urine by utilizing biofunctionalization protocols on the silicon nanostructures. The results indicate significant FL enhancement in metasurface platform that offers a promising pathway for improving biomarker detection in the future.

Rights:

• Creative Commons BY Attribution 4.0 International
  

Keyword: Metasurface platform, AIE FL biosensors, HSA detection, Mult-level immobilizations, Si nanocolumns

Date published: 2024-06-04

Publisher: Wiley

Journal:

• Advanced Optical Materials (ISSN: 21951071) vol. 12 issue. 23 2400868

Funding:

• Ministry of Education, Culture, Sports, Science and Technology JPMXP1223NM5163

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1002/adom.202400868

Related item:

Other identifier(s):

Contact agent:

Updated at: 2024-08-30 12:30:22 +0900

Published on MDR: 2024-08-30 12:30:22 +0900