Download file (5.43 MB)
Download as zip (5.33 MB)

Collection

Citation

Description:

Tissue adhesives suffer from a trade-off relationship between tissue adhesion strength for long-term wound closure and degradation rate for tissue regeneration, which results in the suppression of postoperative wound healing. Here, we report the development of micropore-forming tissue adhesives with an enhanced cell infiltration capacity for tissue regeneration. By leveraging the phase-separation behavior of gelatin modified with hydrogen-bonding moieties, bicontinuous and micropore-forming photocrosslinked hydrogels were developed. The photocrosslinked hydrogels are injectable and enzymatically degradable, showing high tissue adhesive strength against tissues of the collagen membrane, heart, stomach, and large intestine. Moreover, the microporous structure of the hydrogels could enhance fibroblast infiltration through the micropores. These hydrogels could also induce hair follicle regeneration and wound healing in skin incision wound models. This tissue adhesive has enormous potential for promoting wound healing and preventing postoperative complications.

Rights:

• In Copyright
  

Keyword: Hydrogel

Date published: 2025-09-25

Publisher: Elsevier BV

Journal:

• Acta Biomaterialia (ISSN: 17427061) vol. 206 p. 215-224

Funding:

• Japan Society for the Promotion of Science 22H03962
• Inamori Foundation
• Toshiaki Ogasawara Memorial Foundation
• Japan Agency for Medical Research and Development
• Uehara Memorial Foundation

Manuscript type: Author's version (Submitted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5974

First published URL: https://doi.org/10.1016/j.actbio.2025.09.033

Related item:

Other identifier(s):

Contact agent:

Updated at: 2025-12-09 16:30:48 +0900

Published on MDR: 2025-12-09 16:26:06 +0900