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A dividing cell finds precisely the future 3D location to put its daughter cell by sensing the environment far outside its cell boundary. Making such a decision begins at a sub-molecular level of a pair of centrioles, eventually regulating the intricate geometries of a large life form. Thus far, optical imaging and molecular expression delivered little information. Here using theory and experiment, we propose that a scanning dielectric microscope (SDM) may predict the direction where parents would put their daughter with 65% (SD ± 5%) accuracy. The positioning mechanism of a microtubule organization center was monitored live using SDM of the 3D matrices of the hippocampal neuron and a HeLa cell network. We theoretically analyzed electric and magnetic field distributions at resonance for the relative 3D orientation of a pair of centrioles within a cell and also centrioles of the neighboring cells, beyond the optical range. Then microwave imaging revealed that all neighboring cell-centrosomes form a network of coupled vibrations that decides the left–right symmetry, symmetric, and asymmetric cell division. Together with Maxwell’s equation solver, SDM delivers deep insight into the multi-channel signal transmission in biomaterials beyond the optical microscope. For the first time, we combined two widely varied physical characterization tools to understand intelligence in biological systems.

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• In Copyright
  

Keyword: Microtubule network, cell division, centriole, centrosome, sperm

Date published: 2023-06-28

Publisher: Springer Nature Singapore

Journal:

• Lecture Notes in Networks and Systems (ISSN: 23673370) p. 345-371

Funding:

Manuscript type: Author's version (Submitted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5272

First published URL: https://doi.org/10.1007/978-981-99-1916-1_26

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Updated at: 2025-01-15 16:31:39 +0900

Published on MDR: 2025-01-15 16:31:39 +0900