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Description:

Conventional cancer drugs are small molecules that target specific pathways.
We introduced PCMS, a 26 kDa supramolecule combining sensors (S), molecular motors
(M), and switching molecules (C), integrated within a fourth-generation PAMAM structure
(P). PCMS identifies and deactivates cancer cell nucleus dynamics. A decade ago, we
demonstrated programmable, clock-like interactions among the S-C-M components. In
this study, we captured images of fractal patterns formed by chromosomal compartments
and developed a theoretical model of their fractal dynamics. We showed that the nucleus
behaves like a cavity, producing resonance effects similar to Chladni patterns. When the
external agent, PCMS, interacts with this cavity, it generates a fractal pattern. We identified
and mapped five key phase transitions that ultimately lead to the breakdown of cancer
cell nuclei.

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• In Copyright
  

Keyword: cancer, PCMS, cancer drug, design and synthesis drug

Date published: 2024-12-27

Publisher: MDPI AG

Journal:

• Fractal and Fractional (ISSN: 25043110) vol. 9 issue. 1 8

Funding:

Manuscript type: Author's version (Submitted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5275

First published URL: https://doi.org/10.3390/fractalfract9010008

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Updated at: 2025-01-16 16:31:15 +0900

Published on MDR: 2025-01-20 12:31:21 +0900