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説明:

Conventional cancer drugs are small molecules that target specific pathways.
We introduced PCMS, a 26 kDa supramolecule combining sensors (S), molecular motors
(M), and switching molecules (C), integrated within a fourth-generation PAMAM structure
(P). PCMS identifies and deactivates cancer cell nucleus dynamics. A decade ago, we
demonstrated programmable, clock-like interactions among the S-C-M components. In
this study, we captured images of fractal patterns formed by chromosomal compartments
and developed a theoretical model of their fractal dynamics. We showed that the nucleus
behaves like a cavity, producing resonance effects similar to Chladni patterns. When the
external agent, PCMS, interacts with this cavity, it generates a fractal pattern. We identified
and mapped five key phase transitions that ultimately lead to the breakdown of cancer
cell nuclei.

権利情報:

• In Copyright
  

キーワード: cancer, PCMS, cancer drug, design and synthesis drug

刊行年月日: 2024-12-27

出版者: MDPI AG

掲載誌:

• Fractal and Fractional (ISSN: 25043110) vol. 9 issue. 1 8

研究助成金:

原稿種別: 査読前原稿 (Author's original)

MDR DOI: https://doi.org/10.48505/nims.5275

公開URL: https://doi.org/10.3390/fractalfract9010008

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更新時刻: 2025-01-16 16:31:15 +0900

MDRでの公開時刻: 2025-01-20 12:31:21 +0900