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We report the development and evaluation of an oxygen-containing β-type titanium alloy, Ti–12Zr–6Nb–2Mo–2Sn–1.2O. X-ray diffraction confirmed single-phase β stability without martensitic transformation across annealing treatments (1173 K, 60 s–1.8 ks). Texture and EBSD analyses revealed progressive weakening of the {110}〈001〉 with recovery and recrystallization. Tensile tests showed tunable responses: a favorable balance of low modulus (41 GPa) and high strength (>1000 MPa) at short annealing times, and increased ductility after prolonged annealing. Surface characterization indicated similar wettability and moderate roughness compared with cp-Ti; electrochemical tests confirmed stable passive-film formation and corrosion resistance. In vitro assays revealed enhanced fibroblast proliferation but reduced osteoblast adhesion relative to cp-Ti, indicating cell-type-dependent interactions. In vivo subcutaneous implantation in rats demonstrated tissue compatibility comparable to cp-Ti, with mild inflammation, successful regeneration, and normal hematopoiesis, albeit with slightly higher mast-cell degranulation.

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• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

Keyword: β-Titanium alloy, Texture evolution, Ultralow elastic modulus, Biocompatibility, Orthopedic implants

Date published: 2025-11-17

Publisher: Elsevier BV

Journal:

• Journal of Materials Research and Technology (ISSN: 22387854) vol. 39 p. 7613-7625

Funding:

• Japan Society for the Promotion of Science 26249104
• Japan Society for the Promotion of Science KAKENHI 25K01521

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1016/j.jmrt.2025.11.120

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Updated at: 2025-11-18 12:30:09 +0900

Published on MDR: 2025-11-18 12:23:38 +0900