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The corrosion of Mg-based bioabsorbable implanting devices is influenced by implantation environment which dynamically changes by biological response including wound healing. In this study, a hematoma model was created in a rat femur to analyze Mg corrosion with hematoma in the early stage of implantation. The results indicate that hematomas promote Mg corrosion and change the insoluble salt precipitation. The weight loss of the hematoma group was significantly larger than that of the non-hematoma group on day 7. In the non-hematoma group, carbonate and phosphate were detected even on day 1, but the only latter was detected on day 7. In the hematoma group, hydroxide was detected on day 1, followed by the formation of carbonate and phosphate on days 3 and 7. The obtained results suggest the hypoxic and acidic microenvironment in hematomas accelerates the Mg corrosion immediately after implantation, and the subsequent hematoma resorption process leads to the formation of phosphate and carbonate with organic molecules. This study revealed the risk of hematomas as an acceleration factor of the corrosion of Mg-based devices leading to the early implant failure.

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Keyword: magnesium, hematoma, Raman analysis, energy-dispersive x-ray spectroscopy, insoluble salt

Date published: 2024-09-01

Publisher: IOP Publishing

Journal:

• Biomedical Materials (ISSN: 17486041) vol. 19 issue. 5 055043

Funding:

• Nihon Parkerizing Co., Ltd
• Grants-in-Aid for Scientific Research 22H03988

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1088/1748-605x/ad7085

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Updated at: 2024-08-31 08:30:56 +0900

Published on MDR: 2024-08-31 08:30:56 +0900