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Combination of different therapies is an attractive approach for cancer therapy. However, it is a challenge to synchronize different therapies for maximization of therapeutic effects. In this work, a smart composite scaffold that could synchronize magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic Fe3O4 nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes with biodegradable polymers. Irradiation of alternating magnetic field (AMF) could not only increase the scaffold temperature for magnetic hyperthermia but also trigger the release of Dox for chemotherapy. The two functions of magnetic hyperthermia and chemotherapy were synchronized by switching AMF on and off. The synergistic anticancer effects of the composite scaffold were confirmed by in vitro cell culture and in vivo animal experiments. The composite scaffold could efficiently eliminate breast cancer cells under AMF irradiation. Moreover, the scaffold could support proliferation and adipogenic differentiation of mesenchymal stem cells for adipose tissue reconstruction after anticancer treatment. In vivo regeneration experiments showed that the composite scaffolds could effectively maintain their structural integrity and facilitate the infiltration and proliferation of normal cells within the scaffolds. The composite scaffold possesses multi-functions and is attractive as a novel platform for efficient breast cancer therapy.

Rights:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

Keyword: Fe3O4 nanoparticles, Doxorubicin, Thermosensitive liposomes, Composite scaffolds, Manetic hyperthermia, Adipose tissue regeneration

Date published: 2024-02-20

Publisher: Elsevier BV

Journal:

• Biomaterials (ISSN: 01429612) vol. 307 122511

Funding:

• Japan Society for the Promotion of Science 19H04475
• Japan Society for the Promotion of Science 21H03830
• Japan Society for the Promotion of Science 22K19926

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4827

First published URL: https://doi.org/10.1016/j.biomaterials.2024.122511

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Updated at: 2026-02-20 12:30:33 +0900

Published on MDR: 2026-02-20 10:23:02 +0900