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説明:

This paper describes the development of a portable electrochemical sensor for the sensitive and selective detection of dopamine, a clinically important neurotransmitter associated with neurodegenerative diseases such as Parkinson’s and Alzheimer’s. The sensor is based on a three-dimensional phosphorus- and sulfur-doped graphitic carbon nitride hornet’s nest structure, which features a hierarchical porous morphology with multi-open hexagonal gates, abundant voids, and a rough, wave-oriented surface that collectively provide a high surface area and facilitate efficient electrolyte diffusion and dopamine adsorption. Phosphorus and sulfur doping introduces phosphate and sulfate functionalities that enhance charge transfer, improve dopamine binding, and impart high selectivity. When integrated onto a screen-printed carbon electrode, the sensor exhibits a low detection limit of 7.8 nM and a wide linear range from 10 to 500 nM. The platform demonstrates excellent stability, reproducibility, and high recovery of dopamine in human serum and urine samples, highlighting its strong potential for practical clinical and point-of-care applications.

権利情報:

• In Copyright
  

キーワード: Porous g-C3N4; Multifunctional surface interface; Portable electrochemical sensor; Dopamine; Neuronal diseases; Biological samples

刊行年月日: 2024-07-17

出版者: Elsevier BV

掲載誌:

• Analytica Chimica Acta (ISSN: 00032670) vol. 1320 342985

研究助成金:

原稿種別: 査読前原稿 (Author's original)

MDR DOI: https://doi.org/10.48505/nims.6048

公開URL: https://doi.org/10.1016/j.aca.2024.342985

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更新時刻: 2025-12-22 13:04:34 +0900

MDRでの公開時刻: 2025-12-22 16:22:04 +0900