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Although nucleation is considered the first step in the crystallization of glass materials, the structure and properties of the nuclei are not understood well. Influence of nucleation on the structure and dynamics of celecoxib glass was evaluated in this study. The nuclei for Form III were induced by annealing the glass at freezing temperature, and their impact on the relaxation behavior was investigated using thermal analysis and broadband dielectric spectroscopy to find accelerated α relaxation and suppressed β relaxation.

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• In Copyright
  This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.molpharmaceut.3c01116

Keyword: Glass, Nucleation, Crystallization, Relaxation, Cooperative rearranging region

Date published: 2024-04-01

Publisher: American Chemical Society (ACS)

Journal:

• Molecular Pharmaceutics (ISSN: 15438392) vol. 21 issue. 4 p. 1794-1803

Funding:

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4687

First published URL: https://doi.org/10.1021/acs.molpharmaceut.3c01116

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Updated at: 2025-02-24 12:30:14 +0900

Published on MDR: 2025-02-24 12:30:15 +0900