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The management of bleeding is an important aspect of endoscopic surgery to avoid excessive blood loss and minimize pain. In clinical settings, sprayable hemostatic particles are used for their easy delivery, adaptability to irregular shapes, and rapid hydration. However, conventional hemostatic particles present challenges associated with tissue adhesion, and they can also be displaced by blood flow. In a previous study, we introduced tissue adhesive microparticles (C10-sa-MPs) derived from Alaska pollock gelatin modified with decyl groups (C10-sa-ApGltn) that were modified with C10 groups linked via secondary amines. We established that C10-sa-MPs adhere to soft tissues through a hydration mechanism. However, their application as a hemostatic agent was limited by their long hydration times, which was attributed to their high hydrophobicity. In this study, we present a new microparticle type, C10-am-MPs, synthesized by incorporating decanoyl group modifications into ApGltn (C10-am-ApGltn), with C10 groups linked via amide bonds. C10-am-MPs exhibited enhanced hydration characteristics compared to C10-sa-MPs, attributed to superior water absorption facilitated by amide bonds rather than secondary amines. Furthermore, C10-am-MPs demonstrated comparable tissue adhesion properties and underwater adhesion stability to C10-sa-MPs. Notably, C10-am-MPs exhibited accelerated blood coagulation in vitro compared to C10-sa-MPs. The application of C10-am-MPs in an in vivo rat liver hemorrhage model resulted in a hemostatic effect comparable to a commercially available hemostatic particle. These findings highlight the potential utility of C10-am-MPs as an effective hemostatic agent for endoscopic procedures and surgical interventions.

権利情報:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

キーワード: Endoscope submucosal dissection, Bleeding, Hemostatic agent, Microparticles, Tissue adhesion, Underwater stability, Hydrophobic interaction

刊行年月日: 2024-03-19

出版者: Elsevier BV

掲載誌:

• Biomaterials Advances (ISSN: 27729508) 213834

研究助成金:

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4449

公開URL: https://doi.org/10.1016/j.bioadv.2024.213834

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更新時刻: 2026-03-21 08:30:50 +0900

MDRでの公開時刻: 2026-03-20 21:43:04 +0900