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Highly Ordered 1D Fullerene Crystals for Concurrent Control of Macroscopic Cellular Orientation and Differentiation toward Large-Scale Tissue Engineering

MDR Open Deposited

We have demonstrated that aligned 1D fullerene whisker (FW) scaffolds induce myogenic differentiation from myoblast to myotube. FWs were precisely prepared in submicrometer- to micrometer-scale. These microsmeter-scale FWs were aligned on substrates by a simple method using the interfacial alignment. The 1D-patterned architecture of the aligned FW substrate showed significant enhancement of myogenic differentiation and regulated the direction of myotube formation. With its potential to induce myogenic differentiation, and to control growth direction, as well as its biocompatibility, our aligned FW scaffolds are promising platforms for a useful alternative to micropatterned cell scaffolds for tissue engineering.

Alternative title
  • Highly Ordered 1D Fullerene Crystals for Concurrent Control of Macroscopic Cellular Orientation and Differentiation toward Large-Scale Tissue Engineering
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  • 01/06/2015
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  • Accepted manuscript
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