Toward the Establishment of a Harmonized Physicochemical Profiling Platform for Therapeutic Oligonucleotides: A Case Study for Aptamers Where the Higher-Order Structure Influences Physical Properties

Article

Creator

Shoko Takeuchi ; Tomohiko Yamazaki ; Katsutoshi Yamaguchi ; Fusae Komura ; Takahiro Tabata ; Hirotaka Nishi ; Satomi Azumai ; Kanako Miura ; Mai Hirokawa ; Keisuke Ikemoto ; Kohsaku Kawakami

Keyword

oligonucleotide, higher-order structure, thrombin aptamer, G-quadruplex, physicochemical profiling

Date published

2024-07-01

Updated at

2025-06-15 08:30:25 +0900