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Embolic agents have been widely used to treat blood vessel abnormalities in interventional radiology as a minimally invasive procedure. However, only a few biodegradable liquid embolic agents exhibit high embolization performance, biodegradability, and operability. Herein, we report the design of in situ-forming supramolecular nanofiber (SNF) hydrogels as biodegradable liquid embolic agents with the assistance of Bayesian optimization through an active learning pipeline. Chemically modified gelatin with hydrogen-bonding moieties produced fibrin-inspired nanofiber-based hydrogels with a high blood coagulation capacity. The low viscosity of the SNF hydrogels made them injectable using a microcatheter, and the hydrogel showed sufficient tissue adhesion to the blood vessel walls and very weak adhesion to the catheter tubes. Moreover, the SNF hydrogels exhibited high blood compatibility, cytocompatibility, cell-adhesive properties, and biodegradability (in vitro and in vivo). Intravascularly delivered SNF hydrogels induced embolization of rat femoral arteries. This biodegradable liquid embolic agent could be a powerful tool for interventional radiology in the treatment of various diseases, including aortic aneurysm stent grafting, gynecological diseases, and liver cancer.

権利情報:

• In Copyright
  

  This is the pre-peer reviewed version of the following article: A. Nishiguchi, M. Ohta, D. Palai, S. Ito, K. Mori, R. Akagi, C. Bajan, G. Lambard, K. Sodeyama, T. Taguchi, In Situ Forming Supramolecular Nanofiber Hydrogel as a Biodegradable Liquid Embolic Agent for Postembolization Tissue Remodeling. Adv. Healthcare Mater. 2025, 14, 2403784, which has been published in final form at https://doi.org/10.1002/adhm.202403784. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

キーワード: Hydrogel, Embolic agent, Machine learning

刊行年月日: 2024-11-07

出版者: Wiley

掲載誌:

• Advanced Healthcare Materials (ISSN: 21922659) vol. 14 issue. 4 2403784

研究助成金:

• Uehara Memorial Foundation
• Inamori Foundation
• Japan Society for the Promotion of Science 22H03962
• Japan Society for the Promotion of Science 23H01718

原稿種別: 査読前原稿 (Author's original)

MDR DOI: https://doi.org/10.48505/nims.5346

公開URL: https://doi.org/10.1002/adhm.202403784

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更新時刻: 2025-02-26 16:30:29 +0900

MDRでの公開時刻: 2025-02-26 16:30:30 +0900