Kazuyo Ito
(Tokyo University of Agriculture and Technology)
;
Yuta Iijima
(Tokyo University of Agriculture and Technology)
;
Tomoki Misumi
(Tokyo University of Agriculture and Technology)
;
Gen Hayase
(Research Center for Electronic and Optical Materials/Functional Materials Field/Amorphous Material Group, National Institute for Materials Science)
;
Kazuki Tamura
(Hamamatsu University School of Medicine)
;
Kenji Ikushima
(Tokyo University of Agriculture and Technology)
;
Daisuke Yoshino
(Tokyo University of Agriculture and Technology)
Collection
Citation
Description:
(abstract)超音波イメージングを用いて、15日間にわたるがんスフェロイド内部の動態を非侵襲的に評価できることを実証した。散乱に基づく音響パラメータを用いることで、細胞増殖、アポトーシス、壊死に対応する明度および密度の空間的変化を明らかにした。従来の光学イメージング技術は浸透深度の制限や光毒性の影響を受けやすいが、超音波イメージングにより、細胞動態や治療反応の評価に新たな知見をもたらすことが期待される。
Description:
(abstract)We demonstrated that the internal dynamics of cancer spheroids over a 15-day period can be non-invasively evaluated using ultrasound imaging. By employing scattering-based acoustic parameters, we revealed spatial variations in brightness and density that correlate with cell proliferation, apoptosis, and necrosis. While conventional optical imaging techniques are limited by penetration depth and phototoxicity, ultrasound imaging offers new insights into cellular dynamics and therapeutic responses.
Description:
(abstract)超音波イメージングを用いて、15日間にわたるがんスフェロイド内部の動態を非侵襲的に評価できることを実証した。散乱に基づく音響パラメータを用いることで、細胞増殖、アポトーシス、壊死に対応する明度および密度の空間的変化を明らかにした。従来の光学イメージング技術は浸透深度の制限や光毒性の影響を受けやすいが、超音波イメージングにより、細胞動態や治療反応の評価に新たな知見をもたらすことが期待される。
Description:
(abstract)We demonstrated that the internal dynamics of cancer spheroids over a 15-day period can be non-invasively evaluated using ultrasound imaging. By employing scattering-based acoustic parameters, we revealed spatial variations in brightness and density that correlate with cell proliferation, apoptosis, and necrosis. While conventional optical imaging techniques are limited by penetration depth and phototoxicity, ultrasound imaging offers new insights into cellular dynamics and therapeutic responses.
Rights:
Keyword: ultrasound, cancer imaging, spheroid
Date published: 2025-06-13
Publisher: Springer Nature
Journal:
- npj Biomedical Innovations (ISSN: 30051444) vol. 2 issue. 1 18
Funding:
- JSPS KAKENHI No. 21K19893 (超高速ブロックビルド法の確立による臓器オルガノイドの実スケール化への挑戦)
- Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering
- Terumo Life Science Foundation
Manuscript type: Publisher's version (Version of record)
MDR DOI:
First published URL: https://doi.org/10.1038/s44385-025-00026-w
Related item:
Other identifier(s):
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Updated at: 2025-06-18 08:30:18 +0900
Published on MDR: 2025-06-18 08:18:55 +0900
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