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Magnesium (Mg) and its alloys are promising biodegradable implant materials due to their biocompatibility, and ease of corrosion in physiological environment. In the tissue, diffusion of ions and gas released by Mg corrosion reaction will be interfered by extracellular matrix and cells, which may retard the corrosion reaction. Therefore, in the present study, we developed the in vitro model tissue with different diffusion rates to understand the effect of diffusion on the Mg corrosion. A thickener called gellan gum was added to the cell culture medium at appropriate concentrations to simulate tissues with different diffusion rates. The immersion study up to 28 days and the electrochemical studies were performed to evaluate the Mg corrosion behaviour. The pure Mg specimens without thickener showed the highest corrosion rate in both immersion and electrochemical tests. The highest amount of insoluble salt layer with the lowest Mg and highest O concentrations were deposited on the specimen surface without thickener. The microfocus X-ray computer tomography (µCT) analysis confirmed these findings, showing the lowest remaining volume for specimens without thickener. There is an impediment of ion diffusion in the model tissue with increased thickener concentrations, thereby decreasing the corrosion rate. The corrosion rate for 0.2-0.3 wt. % thickener matched in the range of reported in vivo results. Hence, this model proves to be an effective tool for investigating biodegradation and understanding the mechanisms and controlling factors of this phenomenon.

権利情報:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

キーワード: electrochemical impedance spectroscopy, in vitro model tissue , Potentiodynamic polarization, pure Mg, biodegradable metals

刊行年月日: 2025-02-02

出版者: Wiley

掲載誌:

• Journal of Biomedical Materials Research Part A (ISSN: 15493296) vol. 113 issue. 2

研究助成金:

• Japan Society for the Promotion of Science
• Ministry of Education, Culture, Sports, Science and Technology

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1002/jbm.a.37878

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更新時刻: 2025-03-27 08:42:48 +0900

MDRでの公開時刻: 2025-03-27 17:44:00 +0900