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Description:

The heating performance of magnetic nanoparticles for hyperthermia is typically assessed by the specific absorption rate (SARnano), measured under laboratory-specific irradiation conditions. However, since SARnano depends heavily on magnetic field amplitude and frequency, comparing material performance across studies is challenging. This study introduces additional indicators, such as the heating selectivity ratio (which reflects side effects) and the specific power factor (device load), and demonstrates that the ratio of experimentally generated heat to theoretical maximum heat output is a more reliable metric for heat generation efficiency, independent of irradiation conditions. Conventional measurement conditions may not reveal nanoparticles with the highest heating potential, so a predictive method based on blocking temperature and switching field distribution was developed. This method accurately predicts heating behavior for immobilized nanoparticles but needs improvement to account for dipolar interactions and particle rotations. The proposed metrics and framework provide a more robust approach to evaluating nanoparticle performance for hyperthermia.

Rights:

• Creative Commons BY Attribution 4.0 International
  

Keyword: Hyperthermia treatment, Magnetic nanoparticle, Magnetic heating efficiency, Specific absorption rate, Blocking temperature, Switching field distribution

Date published: 2026-06-17

Publisher: Elsevier BV

Journal:

• Materials Today Nano (ISSN: 25888420) vol. 35 100869

Funding:

• Government of Japan Ministry of Education Culture Sports Science and Technology
• Japan Society for the Promotion of Science

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1016/j.mtnano.2026.100869

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Updated at: 2026-06-26 10:43:39 +0900

Published on MDR: 2026-06-26 14:28:24 +0900