Kazuhiko Ishihara (Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University,)
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(abstract)The concepts of bioinspiration and biomimetics that seek to elucidate the
morphology and functions of living organisms and specific reactions within cells, and extraction
of important elements from these concepts to design functional molecules and high-performance
materials are becoming more and more widespread. This review summarizes the progress in
research on hydrogels inspired by the stimuli-responsiveness of cell functions. For application
to a self-regulated release system of insulin to regulate blood glucose levels, various polymer
hydrogels have been designed using bioactive molecules such as enzymes and lectins to sense
glucose concentrations. In addition, as a fully synthetic glucose-responsive hydrogel, a complex
of a polymer having phenylboronic acid groups that form reversible bonds with sugars and a
multivalent hydroxyl group polymer has been researched. This reversible hydrogel system can
be further developed to act as an extracellular matrix in which cells can preferably reside. The
proliferation and differentiation of encapsulated cells in hydrogels are controlled by reversible
changes in the hydrogel properties in response to sugar. Another advantage is that cells can be
safely retrieved by adding sugar to dissociate the hydrogel. These bioinspired polymer
hydrogels can serve as important materials for the development of new medical technologies,
such as the controlled release of bioactive molecules, regulated cell culture environmental
matrices, and applications in layered and three-dimensional cell culture systems to create
organized tissue structures.
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Keyword: Stimuli-responsive hydrogel, cytocompatibility, cell encapsulation, drug delivery system, tissue engineering
Date published: 2025-12-31
Publisher: Taylor & Francis
Journal:
- Science and Technology of Advanced Materials (ISSN: 14686996) vol. 26 issue. 1 2469490
Funding:
Manuscript type: Author's version (Accepted manuscript)
MDR DOI: https://doi.org/10.48505/nims.5381
First published URL: https://doi.org/10.1080/14686996.2025.2469490
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Updated at: 2025-07-16 16:17:04 +0900
Published on MDR: 2025-04-02 18:09:47 +0900
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