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Description:

In this study, the effect of microenvironmental viscosity on the cellular uptake of magnetic nanoparticles and the efficiency of magnetic hyperthermia were investigated by culturing colorectal cancer cells in media of different viscosities. Results showed that the cellular uptake of magnetic nanoparticles significantly decreased with increasing microenvironmental viscosity, which further decreased the intracellular heating effect of magnetic nanoparticles. Furthermore, the proportion of apoptotic cells induced by magnetic hyperthermia was significantly reduced in high viscosity microenvironments, and the most viscous microenvironment exhibited the lowest apoptosis rate. This study revealed the important role of microenvironmental viscosity in regulating the cellular uptake of magnetic nanoparticles and the efficiency of magnetic hyperthermia.

Rights:

• Creative Commons BY-NC Attribution-NonCommercial 4.0 International
  

Keyword: microenvironmental viscosity, cellular uptake, Fe3O4 nanoparticle, anticancer effect

Date published: 2026-04-28

Publisher: Royal Society of Chemistry (RSC)

Journal:

• Nanoscale (ISSN: 20403372) vol. 18 issue. 20 p. 10691-10702

Funding:

• Japan Society for the Promotion of Science 22K19926
• Japan Society for the Promotion of Science 24K03289

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1039/d5nr05112f

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Updated at: 2026-07-15 08:23:46 +0900

Published on MDR: 2026-07-15 10:37:00 +0900