Influence of microenvironmental viscosity on the cellular uptake of Fe
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                    nanoparticles and their anticancer effect

Man Wang; Huajian Chen; Rui Sun; Tianjiao Zeng; Chengyu Lu; Toru Yoshitomi; Naoki Kawazoe; Yingnan Yang; Guoping Chen

doi:10.1039/d5nr05112f

ジャーナル論文 Influence of microenvironmental viscosity on the cellular uptake of Fe ₃ O ₄ nanoparticles and their anticancer effect

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Man Wang, Huajian Chen, Rui Sun, Tianjiao Zeng, Chengyu Lu, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen. Influence of microenvironmental viscosity on the cellular uptake of Fe ₃ O ₄ nanoparticles and their anticancer effect. Nanoscale. 2026, 18 (20), 10691-10702. https://doi.org/10.1039/d5nr05112f

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(abstract)

In this study, the effect of microenvironmental viscosity on the cellular uptake of magnetic nanoparticles and the efficiency of magnetic hyperthermia were investigated by culturing colorectal cancer cells in media of different viscosities. Results showed that the cellular uptake of magnetic nanoparticles significantly decreased with increasing microenvironmental viscosity, which further decreased the intracellular heating effect of magnetic nanoparticles. Furthermore, the proportion of apoptotic cells induced by magnetic hyperthermia was significantly reduced in high viscosity microenvironments, and the most viscous microenvironment exhibited the lowest apoptosis rate. This study revealed the important role of microenvironmental viscosity in regulating the cellular uptake of magnetic nanoparticles and the efficiency of magnetic hyperthermia.

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