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Description:

To avoid the toxic effect of released nickel ions and compounds from conventional stainless steels, nickel-free austenitic stainless steels have been developed. We previously established a new manufacturing process to produce nickel-free austenitic stainless steel that involves nitrogen adsorption treatment. Although the cytocompatibility of nickel-free austenitic stainless steel produced using this method has been evaluated using two viability assay, molecular level analysis, such as gene expression analysis, has not been previously performed. In the present study, the cytotoxicity of our nickel-free austenitic stainless steel, as well as of commercially available metal materials, was evaluated by analysis of heat shock protein 70B’ (HSP70B’) gene expression as a stress response marker.

Rights:

• Creative Commons BY Attribution 4.0 International
  

Keyword: Heat Shock Protein 70B’, cytocompatibility, human osteoblast-like SaOS-2 cells, human monocyte THP-1 cells

Date published: 2007-06-20

Publisher: Bentham Science Publishers Ltd.

Journal:

• The Open Biotechnology Journal (ISSN: 18740715) vol. 1 p. 14-17

Funding:

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.2174/1874070700701010014

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Updated at: 2025-09-18 12:30:21 +0900

Published on MDR: 2025-09-18 12:23:06 +0900