Article The effect of branched structures of alkyl groups on tissue adhesiveness and biocompatibility of alkyl groups-modified Alaska pollock gelatin-based adhesives

Satsuki Minamisakamoto ; Hiyori Komatsu SAMURAI ORCID (National Institute for Materials Science) ; Shiharu Watanabe (National Institute for Materials Science) ; Shima Ito SAMURAI ORCID (National Institute for Materials Science) ; Hatsune Nishino ; Tetsushi Taguchi SAMURAI ORCID (National Institute for Materials Science)

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Satsuki Minamisakamoto, Hiyori Komatsu, Shiharu Watanabe, Shima Ito, Hatsune Nishino, Tetsushi Taguchi. The effect of branched structures of alkyl groups on tissue adhesiveness and biocompatibility of alkyl groups-modified Alaska pollock gelatin-based adhesives. Materials & Design. 2025, 258 (), 114665. https://doi.org/10.1016/j.matdes.2025.114665

Description:

(abstract)

Tissue adhesives are widely used to prevent air leakage from the lungs and bleeding from vascular anastomoses. However, currently used tissue adhesives still face challenges with either tissue adhesion or biocompatibility. We previously reported tissue adhesives composed of straight alkyl group-modified Alaska pollock gelatin (ApGltn) and pentaerythritol poly (ethylene glycol) ether tetrasuccinimidyl glutarate (4S-PEG). The developed adhesives have sufficient tissue adhesive strength and biocompatibility for biomedical applications; however, the effect of the branched structures of the alkyl groups on these functions has not yet been clarified. In this study, we evaluated the tissue adhesiveness and biocompatibility of three tissue adhesives based on straight/branched alkyl group-modified ApGltns and 4S-PEG. The results showed that branched alkyl group-modified ApGltns-based adhesives had higher tissue adhesion strength than straight alkyl-ApGltn. Furthermore, the burst strength of the branched alkyl group modified ApGltn-based adhesives 2-fold higher compared to commercial Fibrin. In addition, they were completely biodegraded in rat subcutaneous tissue within 56 days without causing severe inflammation.

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Keyword: in situ hydrogel, tissue adhesion, Alaska pollock-derived gelatin

Date published: 2025-09-11

Publisher: Elsevier BV

Journal:

  • Materials & Design (ISSN: 02641275) vol. 258 114665

Funding:

  • Japan Society for the Promotion of Science 24K21677
  • Japan Society for the Promotion of Science 22KJ0418
  • Japan Society for the Promotion of Science 23K26411
  • Japan Society for the Promotion of Science 24KJ0500
  • Japan Society for the Promotion of Science 23K25216
  • Japan Society for the Promotion of Science 24K22399

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5911

First published URL: https://doi.org/10.1016/j.matdes.2025.114665

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Updated at: 2025-11-18 08:30:03 +0900

Published on MDR: 2025-11-18 08:22:59 +0900

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