The effect of branched structures of alkyl groups on tissue adhesiveness and biocompatibility of alkyl groups-modified Alaska pollock gelatin-based adhesives

Satsuki Minamisakamoto; Hiyori Komatsu; Shiharu Watanabe; Shima Ito; Hatsune Nishino; Tetsushi Taguchi

doi:10.1016/j.matdes.2025.114665

論文 The effect of branched structures of alkyl groups on tissue adhesiveness and biocompatibility of alkyl groups-modified Alaska pollock gelatin-based adhesives

Satsuki Minamisakamoto ; Hiyori Komatsu (National Institute for Materials Science) ; Shiharu Watanabe (National Institute for Materials Science) ; Shima Ito (National Institute for Materials Science) ; Hatsune Nishino ; Tetsushi Taguchi (National Institute for Materials Science)

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Satsuki Minamisakamoto, Hiyori Komatsu, Shiharu Watanabe, Shima Ito, Hatsune Nishino, Tetsushi Taguchi. The effect of branched structures of alkyl groups on tissue adhesiveness and biocompatibility of alkyl groups-modified Alaska pollock gelatin-based adhesives. Materials & Design. 2025, 258 (), 114665. https://doi.org/10.1016/j.matdes.2025.114665

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(abstract)

Tissue adhesives are widely used to prevent air leakage from the lungs and bleeding from vascular anastomoses. However, currently used tissue adhesives still face challenges with either tissue adhesion or biocompatibility. We previously reported tissue adhesives composed of straight alkyl group-modified Alaska pollock gelatin (ApGltn) and pentaerythritol poly (ethylene glycol) ether tetrasuccinimidyl glutarate (4S-PEG). The developed adhesives have sufficient tissue adhesive strength and biocompatibility for biomedical applications; however, the effect of the branched structures of the alkyl groups on these functions has not yet been clarified. In this study, we evaluated the tissue adhesiveness and biocompatibility of three tissue adhesives based on straight/branched alkyl group-modified ApGltns and 4S-PEG. The results showed that branched alkyl group-modified ApGltns-based adhesives had higher tissue adhesion strength than straight alkyl-ApGltn. Furthermore, the burst strength of the branched alkyl group modified ApGltn-based adhesives 2-fold higher compared to commercial Fibrin. In addition, they were completely biodegraded in rat subcutaneous tissue within 56 days without causing severe inflammation.

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