Article Locally implantable nanofibre meshes by sustained release of temozolomide for combined thermo-chemotherapy to treat glioblastoma

Emiho Oe ORCID (National Institute for Materials Science) ; Nanami Fujisawa SAMURAI ORCID (National Institute for Materials Science) ; Lili Chen ORCID (National Institute for Materials Science) ; Koichiro Uto SAMURAI ORCID (National Institute for Materials Science) ; Yoshitaka Matsumoto ORCID ; Mitsuhiro Ebara SAMURAI ORCID (National Institute for Materials Science)

MS_New Journal of Chemistry_Oe.pdf
Download file (1.42 MB)
Download as zip (1.36 MB)
Collection

Citation
Emiho Oe, Nanami Fujisawa, Lili Chen, Koichiro Uto, Yoshitaka Matsumoto, Mitsuhiro Ebara. Locally implantable nanofibre meshes by sustained release of temozolomide for combined thermo-chemotherapy to treat glioblastoma. New Journal of Chemistry. 2023, 47 (12), 5816-5824. https://doi.org/10.1039/d3nj00534h
SAMURAI

Description:

(abstract)

Glioblastoma (GBM) is a highly malignant type of brain tumour that arises from astrocytes or supportive brain tissue in adults. Although there are several therapeutic options, recurrence rates remain high, with a 5 year survival rate expectancy of less than 10%. This study investigates nanofibre meshes that enable the long-term release of temozolomide (TMZ) over a 4 week period by controlling the fibre morphologies. The nanofibre meshes were fabricated via the electrospinning of a biodegradable polymer, poly(ε-caprolactone) (PCL). The obtained meshes were flexible and implantable as a local intracranial drug delivery platform. The nanofibre meshes also carry magnetic nanoparticles (MNPs) that enable the combined therapy of hyperthermia/chemotherapy corresponding to an alternating magnetic field (AMF). The heat generation behaviour of the nanofibre meshes was successfully adjusted in a hyperthermic temperature range (∼42.6 °C). The TMZ/MNP-loaded nanofibre meshes showed a 76% reduction in the cell viability of GBM cancer (T98G) cells through the synergistic effect of hyperthermia and chemotherapy. These results indicated the potential applications of nanofibre meshes as an implantable intracranial drug delivery system as an adjunct to surgery and radiation for GBM patients.

Rights:

Keyword: nanofibers, glioblastoma , cancer , chemotherapy

Date published: 2023-02-21

Publisher: Royal Society of Chemistry (RSC)

Journal:

  • New Journal of Chemistry (ISSN: 13699261) vol. 47 issue. 12 p. 5816-5824

Funding:

  • Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (B) [JP19H04476]
  • Japan Society for the Promotion of Science Grant-in-Aid for Transformative Research Areas (A) [JP20H05877]

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4836

First published URL: https://doi.org/10.1039/d3nj00534h

Related item:

Other identifier(s):

Contact agent:

Updated at: 2024-10-11 12:30:30 +0900

Published on MDR: 2024-10-11 12:30:30 +0900

Filename Size
Filename MS_New Journal of Chemistry_Oe.pdf (Thumbnail)
application/pdf 		Size 1.42 MB Detail