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Description:

Liquid-liquid phase separation towards the formation of synthetic coacervate droplets represents a rapidly advancing frontier in the fields of synthetic biology, material science, and biomedicine. These artificial constructures mimic the biophysical principles and dynamic features of natural biomolecular condensates that are pivotal for cellular regulation and organization. Via adapting biological concepts, synthetic condensates with dynamic phase-separation control provide crucial insights into the fundamental cell processes and regulation of complex biological pathways. They are increasingly designed with the ability to display more complex and ambitious cell-like features and behaviors, which offer innovative solutions for cytomimetic modeling and engineering active materials with sophisticated functions. In this minireview, we highlight recent advancements in the design and construction of synthetic coacervate droplets; including their biomimicry structure and organization to replicate life-like properties and behaviors, and the dynamic control towards engineering active coacervates. Moreover, we highlight the unique applications of synthetic coacervates as catalytic centers and promising delivery vehicles, so that these biomimicry assemblies can be translated into practical applications.

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• Creative Commons BY-NC Attribution-NonCommercial 4.0 International
  

  This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Keyword: biomimicry, coacervate, condensate, liquid-liquid phase separation, synthetic cell

Date published: 2025-02-17

Publisher: Wiley

Journal:

• Angewandte Chemie International Edition (ISSN: 14337851) vol. 64 issue. 8 e202418431

Funding:

• National Natural Science Foundation of China 52403198
• National Natural Science Foundation of China 12302410
• Sichuan Province Science and Technology Support Program 2024YFHZ0356
• Fundamental Research Funds for the Central Universities
• Federal Ministry of Education and Research of Germany (BMBF) and the Max Planck Society (Max Planck Consortium for Synthetic Biology (MaxSynBio))
• Projekt DEAL (Open Access funding)

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1002/anie.202418431

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Updated at: 2025-02-23 22:49:33 +0900

Published on MDR: 2025-02-23 22:49:33 +0900