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説明:

Liquid-liquid phase separation towards the formation of synthetic coacervate droplets represents a rapidly advancing frontier in the fields of synthetic biology, material science, and biomedicine. These artificial constructures mimic the biophysical principles and dynamic features of natural biomolecular condensates that are pivotal for cellular regulation and organization. Via adapting biological concepts, synthetic condensates with dynamic phase-separation control provide crucial insights into the fundamental cell processes and regulation of complex biological pathways. They are increasingly designed with the ability to display more complex and ambitious cell-like features and behaviors, which offer innovative solutions for cytomimetic modeling and engineering active materials with sophisticated functions. In this minireview, we highlight recent advancements in the design and construction of synthetic coacervate droplets; including their biomimicry structure and organization to replicate life-like properties and behaviors, and the dynamic control towards engineering active coacervates. Moreover, we highlight the unique applications of synthetic coacervates as catalytic centers and promising delivery vehicles, so that these biomimicry assemblies can be translated into practical applications.

権利情報:

• Creative Commons BY-NC Attribution-NonCommercial 4.0 International
  This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

キーワード: biomimicry, coacervate, condensate, liquid-liquid phase separation, synthetic cell

刊行年月日: 2025-02-17

出版者: Wiley

掲載誌:

• Angewandte Chemie International Edition (ISSN: 14337851) vol. 64 issue. 8 e202418431

研究助成金:

• National Natural Science Foundation of China 52403198
• National Natural Science Foundation of China 12302410
• Sichuan Province Science and Technology Support Program 2024YFHZ0356
• Fundamental Research Funds for the Central Universities
• Federal Ministry of Education and Research of Germany (BMBF) and the Max Planck Society (Max Planck Consortium for Synthetic Biology (MaxSynBio))
• Projekt DEAL (Open Access funding)

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1002/anie.202418431

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更新時刻: 2025-02-23 22:49:33 +0900

MDRでの公開時刻: 2025-02-23 22:49:33 +0900