Geometrically engineered organoid units and their assembly for pre-construction of organ structures

Ayaka Kadotani; Gen Hayase; Daisuke Yoshino

doi:10.1063/5.0222866

論文 Geometrically engineered organoid units and their assembly for pre-construction of organ structures

Ayaka Kadotani ; Gen Hayase (National Institute for Materials Science) ; Daisuke Yoshino

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引用

Ayaka Kadotani, Gen Hayase, Daisuke Yoshino. Geometrically engineered organoid units and their assembly for pre-construction of organ structures. APL Bioengineering. 2024, 8 (4), 046112. https://doi.org/10.1063/5.0222866

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説明:

(abstract)

細胞の種類や細胞外マトリックス、接着成分に依存しない様々な形状のオルガノイドユニットの作製、連結、組み立て方法（ユニット構築法）を確立した。また、ヒトの腎臓を構成する3種類の実質細胞と間質細胞を用いて腎組織様構造を作製し、ユニット間のクロストークの可能性を示唆する知見を得た。

説明:

(abstract)

We established a method for fabricating, connecting, and assembling organoid units of various shapes independent of cell type, extracellular matrix, and adhesive composition (unit construction method). We also fabricated kidney tissue-like structures using three types of parenchymal and interstitial cells that compose the human kidney and obtained findings suggesting the possibility of crosstalk between the units.

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