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In this study, a novel implantable in situ therapeutic composite scaffold platform (ALA@lipo/Au/Gel/PGA) was developed based on a porous scaffold composed of biocompatible gelatin and polyglutamic acid (PGA). This platform incorporated the photothermal agent Au nanorods (AuNRs) and thermosensitive liposomes encapsulated with the photosensitizer precursor 5-aminolevulinic acid (ALA). Due to the satisfactory photothermal conversion effect of the ALA@lipo/Au/Gel/PGA composite scaffold, the use of near-infrared (NIR) light not only ablated the cancer cells in the scaffold through photothermal therapy (PTT) but also induced the accelerated release of encapsulated ALA from the thermosensitive liposomes. After uptake, ALA could generate cytotoxic reactive oxygen species to increase tumour cell elimination efficiency via photodynamic therapy (PDT). Both in vitro and in vivo experiments demonstrated the synergistic anticancer effects of the composite scaffold.

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• In Copyright
  

Keyword: thermosensitive liposome, nanomedicine, photothermal, composite scaffolds, cancer therapy

Date published: 2025-07-11

Publisher: Royal Society of Chemistry (RSC)

Journal:

• Materials Horizons (ISSN: 20516347) vol. 12 issue. 20 p. 8654-8666

Funding:

• Japan Society for the Promotion of Science 19H04475
• Japan Society for the Promotion of Science 24K03289

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5808

First published URL: https://doi.org/10.1039/d5mh00888c

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Updated at: 2025-10-14 17:18:53 +0900

Published on MDR: 2026-07-11 08:24:31 +0900