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Description:

In this study, a heparin-functionalized scaffold is designed to mimic the GFs reservoir function of extracellular matrix (ECM). Owing to its heparin-binding domain, heparin-binding epidermal growth factor-like growth factor (HB-EGF) is effectively and spatially captured by heparin-functionalized scaffold. Furthermore, the strong interaction between heparin and heparin-binding domain confers excellent stability of the immobilized HB-EGF in scaffold over a long period. The heparin-functionalized scaffold immobilized with HB-EGF facilitates cell adhesion and promotes proliferation of human mesenchymal stem cells (hMSCs), while not inducing their differentiation during proliferation.

Rights:

• Creative Commons BY-NC Attribution-NonCommercial 4.0 International
  

Keyword: HB-EGF, heparin, hMSCs, immobilization, porous scaffold, tissue engineering

Date published: 2025-10-01

Publisher: Wiley

Journal:

• Advanced Healthcare Materials (ISSN: 21922640) e02771

Funding:

• Japan Science and Technology Agency JPMJSP2124
• Japan Society for the Promotion of Science 24K03289

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1002/adhm.202502771

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Updated at: 2025-10-21 16:06:17 +0900

Published on MDR: 2025-10-21 15:43:25 +0900