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In this study, a heparin-functionalized scaffold is designed to mimic the GFs reservoir function of extracellular matrix (ECM). Owing to its heparin-binding domain, heparin-binding epidermal growth factor-like growth factor (HB-EGF) is effectively and spatially captured by heparin-functionalized scaffold. Furthermore, the strong interaction between heparin and heparin-binding domain confers excellent stability of the immobilized HB-EGF in scaffold over a long period. The heparin-functionalized scaffold immobilized with HB-EGF facilitates cell adhesion and promotes proliferation of human mesenchymal stem cells (hMSCs), while not inducing their differentiation during proliferation.

権利情報:

• Creative Commons BY-NC Attribution-NonCommercial 4.0 International
  

キーワード: HB-EGF, heparin, hMSCs, immobilization, porous scaffold, tissue engineering

刊行年月日: 2025-10-01

出版者: Wiley

掲載誌:

• Advanced Healthcare Materials (ISSN: 21922640) e02771

研究助成金:

• Japan Science and Technology Agency JPMJSP2124
• Japan Society for the Promotion of Science 24K03289

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1002/adhm.202502771

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更新時刻: 2025-10-21 16:06:17 +0900

MDRでの公開時刻: 2025-10-21 15:43:25 +0900