論文 Sprayable Tissue Adhesive Microparticle–Magnetic Nanoparticle Composites for Local Cancer Hyperthermia

伊藤 椎真 (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group, National Institute for Materials ScienceROR) ; 長坂 和寛 (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group, National Institute for Materials ScienceROR) ; 小松 ひより SAMURAI ORCID (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group, National Institute for Materials ScienceROR) ; 間宮 広明 SAMURAI ORCID (Research Center for Magnetic and Spintronic Materials/Green Magnetic Materials Group, National Institute for Materials ScienceROR) ; 竹口 雅樹 SAMURAI ORCID (Center for Basic Research on Materials/Advanced Materials Characterization Field/In-situ Electron Microscopy Technique Group, National Institute for Materials ScienceROR) ; 西口 昭広 SAMURAI ORCID (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group, National Institute for Materials ScienceROR) ; 田口 哲志 SAMURAI ORCID (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Polymeric Biomaterials Group, National Institute for Materials ScienceROR)

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引用
伊藤 椎真, 長坂 和寛, 小松 ひより, 間宮 広明, 竹口 雅樹, 西口 昭広, 田口 哲志. Sprayable Tissue Adhesive Microparticle–Magnetic Nanoparticle Composites for Local Cancer Hyperthermia . Biomaterials Advances. 2023, 156 (), 213707. https://doi.org/10.1016/j.bioadv.2023.213707
SAMURAI

説明:

(abstract)

Incomplete removal of early-stage gastrointestinal cancers by endoscopic treatments often leads to recurrence induced by residual cancer cells. To completely remove or kill cancer tissues and cells and prevent recurrence, chemotherapy, radiotherapy, and hyperthermia using biomaterials with drugs or nanomaterials are usually administered following endoscopic treatments. However, there are no biomaterials that can be applied using endoscopic devices to locally kill cancer tissues and cells. We previously reported that decyl group-modified Alaska pollock gelatin-based microparticles (denoted C10MPs) can adhere to gastrointestinal tissues under wet conditions through the formation of a colloidal gel driven by hydrophobic interactions. In this study, we combined C10MPs with superparamagnetic iron oxide nanoparticles (SPIONs) to develop a sprayable heat-generating nanomaterial (denoted SP/C10MP) for local hyperthermia of gastrointestinal cancers. The rheological property, tissue adhesion strength, burst strength, and underwater stability of SP/C10MP were improved through decyl group modification and SPION addition. Moreover, SP/C10MP that adhered to gastrointestinal tissues formed a colloidal gel, which locally generated heat in response to an alternating magnetic field. SP/C10MP successfully killed cancer tissues and cells in colon cancer-bearing mouse models in vitro and in vivo. Therefore, SP/C10MP has the potential to locally kill residual cancer tissues and cells after endoscopic treatments.

権利情報:

キーワード: Endoscope surgery, local hyperthermia, tissue adhesion, underwater stability, hydrophobic interaction

刊行年月日: 2023-11-27

出版者: Elsevier B.V.

掲載誌:

  • Biomaterials Advances (ISSN: 27729508) vol. 156 213707

研究助成金:

  • JSPS科研費 22J20039
  • JSPS科研費 23H01718
  • JSPS科研費 22H03962
  • JSPS科研費 22K19947

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4285

公開URL: https://doi.org/10.1016/j.bioadv.2023.213707

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更新時刻: 2025-11-28 08:30:21 +0900

MDRでの公開時刻: 2025-11-28 08:22:45 +0900

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