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説明:

This study investigates the impact of hydrophobic modification on the immunogenicity, cytotoxicity, and inflammatory response of Alaska pollock gelatin (ApGltn) microparticles (MPs). Gelatin, known for its inherent biocompatibility, was modified with decyl group (C10) to explore potential alterations in its interaction with the immune system. Immunogenicity was evaluated through the measurement of material-specific IgM and IgG responses, indicating no significant increase post-modification. Cytotoxicity against Caco-2 cell lines and NF-kB-mediated LPS-induced inflammation were also assessed, revealing no exacerbation by the modified MPs. Furthermore, C10-modification with different types of linkage such as secondary amine and amide structure did not influence immune reactivity. These findings suggest that C10-modification maintains the non-immunogenicity and biocompatibility of gelatin MPs, supporting their potential use in biomedical applications.

権利情報:

• In Copyright
  

  This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-024-00643-2

キーワード: Alaska pollock gelatin, Microparticles, Hydrophobic modification

刊行年月日: 2024-08-09

出版者: Springer Science and Business Media LLC

掲載誌:

• Analytical Sciences (ISSN: 09106340) vol. 40 p. 2053-2061

研究助成金:

• Grant-in-Aid for Transformative Research Areas 20H05876
• Grant-in-Aid for Transformative Research Areas 20H05872

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5081

公開URL: https://doi.org/10.1007/s44211-024-00643-2

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更新時刻: 2025-10-21 16:16:33 +0900

MDRでの公開時刻: 2025-10-21 16:14:42 +0900