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Crystallization behavior of ibuprofen glass was investigated with focus on the nucleation process and its possible relevance to the cooperatively rearranging region (CRR). The nucleation temperature range of ibuprofen glass was determined by annealing it at various temperatures, followed by observation of the probability of cold crystallization. The temperature to provide the highest probability of nucleation was −15 °C. The effect of the addition of a polymer was also investigated to find that it enhanced and suppressed the crystallization depending on the polymer species and its amount added. The added polymer seemed to influence both nucleation and crystal growth processes by decreasing the glass/nuclei interfacial tension and increasing viscosity, respectively. In addition, the coincidence of the size of CRR in the presence of the polymer with the critical size of nuclei was assumed to enhance nucleation. This finding provides a novel viewpoint for clarifying the nucleation mechanism from supercooled liquids and glasses.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: Pharmaceutical glass, Nucleation, Crystallization, Cooperatively rearranging region

刊行年月日: 2025-02-20

出版者: American Chemical Society (ACS)

掲載誌:

• The Journal of Physical Chemistry B (ISSN: 15206106) vol. 129 issue. 7 p. 2096-2104

研究助成金:

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1021/acs.jpcb.4c07005

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更新時刻: 2025-11-25 12:30:10 +0900

MDRでの公開時刻: 2025-11-25 12:23:33 +0900