Download file (1.4 MB)
Download as zip (985 KB)

Collection

Citation

Description:

A redox-neutral Fe-electrocatalytic deoxygenative Giese reaction is reported.
Hydroxyl groups are among the most abundant functional groups; therefore, the development of efficient methods for their transformation is of significant importance in medicinal and process chemistry. Here, we present a redox-neutral Giese reaction that proceeds via anodic oxidation to generate phosphonium ions, combined with cathodic reduction to furnish low-valent Fe catalysts. This reaction represents a promising example of a redox-neutral transformation enabled by an Fe catalyst and electrochemistry. The results obtained in this study will facilitate the exploration of a broad range of novel reactions employing this redox cycle in the future.

Rights:

• Creative Commons BY-NC-ND Attribution-NonCommercial-NoDerivs 4.0 International
  

Keyword: Fe-electrocatalysis, Deoxygenative Giese reaction, Redox-neutral electrochemistry, C–C bond formation, Hydroxyl group functionalization

Date published: 2025-09-26

Publisher: Springer Science and Business Media LLC

Journal:

• Nature Communications (ISSN: 20411723) vol. 16 issue. 1 8379

Funding:

• Research Grants Council, University Grants Committee ECS, HKUST 26302024
• Hong Kong University of Science and Technology Start-up funds (Project No. R9820)

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1038/s41467-025-63515-x

Related item:

Other identifier(s):

Contact agent:

Updated at: 2025-12-24 15:09:39 +0900

Published on MDR: 2025-12-24 16:20:28 +0900