Article Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery

Tianjiao Zeng SAMURAI ORCID ; Lusi Chen ; Toru Yoshitomi SAMURAI ORCID ; Naoki Kawazoe SAMURAI ORCID ; Yingnan Yang ; Guoping Chen SAMURAI ORCID

biomedicines-13-01899-v2.pdf
Download file (1.56 MB)
Download as zip (1.31 MB)
Collection

Citation
Tianjiao Zeng, Lusi Chen, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen. Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery. Biomedicines. 2025, 13 (8), 1899. https://doi.org/10.3390/biomedicines13081899

Description:

(abstract)

Tumor treatments have substantially advanced through various approaches, including chemotherapy, radiotherapy, immunotherapy, and gene therapy. However, efficient treatment necessitates overcoming physiological barriers that impede the delivery of therapeutic agents to target sites. Drug delivery systems (DDSs) are a prominent research area, particularly in tumor therapy. This review provides a comprehensive overview of hydrogel-based DDSs for tumor treatment, focusing on the strategies and designs of DDSs based on the unique pathophysiological characteristics of tumors. The design and preparation of hydrogel systems for DDSs are summarized and highlighted. The challenges and opportunities for translating hydrogel-based DDSs into clinical applications are discussed.

Rights:

Keyword: hydrogel, drug delivery system, antitumor therapy, combination therapy

Date published: 2025-08-04

Publisher: MDPI AG

Journal:

  • Biomedicines (ISSN: 22279059) vol. 13 issue. 8 1899

Funding:

  • JSPS KAKENHI 19H04475
  • JSPS KAKENHI 24K03289

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.3390/biomedicines13081899

Related item:

Other identifier(s):

Contact agent:

Updated at: 2025-09-02 16:30:25 +0900

Published on MDR: 2025-09-02 12:24:59 +0900

Filename Size
Filename biomedicines-13-01899-v2.pdf (Thumbnail)
application/pdf 		Size 1.56 MB Detail