Article Development of Drug-loaded Shape-Memory Polymer Urethral Stent (SMPUS) for treatment of Prostatic Urethral Obstruction (PUO)

Alaa Fehaid SAMURAI ORCID (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Smart Polymers Group, National Institute for Materials Science) ; Koichiro Uto SAMURAI ORCID (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Smart Polymers Group, National Institute for Materials Science) ; Toshimasa Homma (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Smart Polymers Group, National Institute for Materials Science) ; Ailifeire Fulati SAMURAI ORCID (Research Center for Macromolecules and Biomaterials/Macromolecules Field/Data-driven Polymer Design Group, National Institute for Materials Science) ; Maëlys Tisserant ; Jun Nakanishi SAMURAI ORCID (Research Center for Macromolecules and Biomaterials/Biomaterials Field/Mechanobiology Group, National Institute for Materials Science) ; Mitsuhiro Ebara SAMURAI ORCID (Research Center for Macromolecules and Biomaterials/Biomaterials Field, National Institute for Materials Science)

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Alaa Fehaid, Koichiro Uto, Toshimasa Homma, Ailifeire Fulati, Maëlys Tisserant, Jun Nakanishi, Mitsuhiro Ebara. Development of Drug-loaded Shape-Memory Polymer Urethral Stent (SMPUS) for treatment of Prostatic Urethral Obstruction (PUO). ACS OMEGA. 2025, 10 (32), 36672-36681. https://doi.org/10.1021/acsomega.5c05903

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(abstract)

Prostatic Urethral Obstruction (PUO) is the urethral narrowing by the external pressure of an enlarged prostate, which hinders the ability to pass urine normally. The most common reasons for the enlarged prostate are prostate cancer and benign prostatic hyperplasia (BPH). In this study, we aimed to develop a drug-loaded shape-memory polymer urethral stent (SMPUS) to address the PUO. The SMPUS was designed to combine both mechanical and chemical/herbal treatment of PUO. Successfully, SMPUS shows a potential mechanical efficacy through its shape-memory properties that ensure the patency of the urethral lumen by restoring its tube-like stent shape by flushing with hot water at its melting temperature (Tm). Additionally, the in-vitro drug release investigation shows the capability of SMPUS to serve as a versatile drug delivery platform, after further in-vivo investigation, enabling the release of the selected drugs to treat the primary diseases associated with PUO while mitigating the systemic side effects associated with conventional treatments. Both polymer and drug concentrations can be modulated to achieve the required mechanical and thermal properties based on the case progress. This adaptability of the developed SMPUS allows for future in-vivo and clinical trials in medical applications.

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Keyword: Shape-memory polymer, Prostate, Drug

Date published: 2025-08-19

Publisher: ACS

Journal:

  • ACS OMEGA (ISSN: 24701343) vol. 10 issue. 32 p. 36672-36681

Funding:

  • JSPS 24KF0165

Manuscript type: Publisher's version (Version of record)

MDR DOI:

First published URL: https://doi.org/10.1021/acsomega.5c05903

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Updated at: 2025-12-10 16:30:19 +0900

Published on MDR: 2025-12-10 16:25:16 +0900

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