Article Ultrasensitive Visual Tracking of Toxic Cyanide Ions in Biological Samples Using Biocompatible Metal–Organic Frameworks Architectures

Islam M. El-Sewify ; Mohamed A. Shenashen ORCID (National Institute for Materials ScienceROR) ; Rasha F. El-Agamy ; Mohammed S. Selim ; Norah F. Alqahtani ; Ahmed Elmarakbi ; Mitsuhiro Ebara SAMURAI ORCID (National Institute for Materials ScienceROR) ; Mahmoud M. Selim ; Mostafa M.H. Khalil ; Sherif A. El-Safty SAMURAI ORCID (National Institute for Materials ScienceROR)

Ultrasensitive Visual Tracking of Toxic Cyanide Ions in Biological Samples Using Biocompatible Metal–organic Frameworks Architectures.pdf
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Islam M. El-Sewify, Mohamed A. Shenashen, Rasha F. El-Agamy, Mohammed S. Selim, Norah F. Alqahtani, Ahmed Elmarakbi, Mitsuhiro Ebara, Mahmoud M. Selim, Mostafa M.H. Khalil, Sherif A. El-Safty. Ultrasensitive Visual Tracking of Toxic Cyanide Ions in Biological Samples Using Biocompatible Metal–Organic Frameworks Architectures. Journal of Hazardous Materials. 2023, 465 (), 133271. https://doi.org/10.1016/j.jhazmat.2023.133271
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(abstract)

The extraordinary accumulation of cyanide ions within biological cells is a severe health risk. Detecting and tracking toxic cyanide ions within these cells by simple and ultrasensitive methods are of immense curiosity. Here we report continuous tracking of ultimate levels of CN-ions in HeLa cells using biocompatible branching molecular architectures (BMAs). Batch-contact methods were used to assess the potential of hollow-nest architecture for inhibition/evaluation of toxicant CN-ions in HeLa cells. The nanorod BMAs revealed significant potential capabilities for monitoring and tracking of CN-ions in biological trials within seconds. These results provide sufficient evidence of the compatibility of BMAs during HeLa cell exposure. Under certain conditions, the BMAs were used for in-vitro fluorescence tracking/sensing of CN-in HeLa cells. The cliff swallow nest may have the potential to reduce the health hazards associated with toxicant exposure in biological cells.

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Keyword: Visual Monitoring, Cyanide, HeLa cells, In-vitro, Biocompatible, Al-MOF, Nanorods

Date published: 2023-12-16

Publisher: Elsevier BV

Journal:

  • Journal of Hazardous Materials (ISSN: 03043894) vol. 465 133271

Funding:

Manuscript type: Author's version (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5015

First published URL: https://doi.org/10.1016/j.jhazmat.2023.133271

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Updated at: 2025-12-19 21:00:42 +0900

Published on MDR: 2025-12-19 21:00:32 +0900

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