Download file (2.99MB)
Download as zip (2.88MB)

コレクション

引用

説明:

In this work, a controllable interconnected three-dimensional (3D) porous scaffold with surface micropatterning was fabricated. Nozzle-based Aerojet dispenser 3D printing was used to form printed ice as a fugitive ink combined with a freeze-drying method of gelatin/nano-silica/poly lactic-co-glycolic acid (PLGA) and ice particulates to fabricate a composite scaffold with supporting properties. Several designs of printed ice were explored and the HUVECs' behavior on different surface patterns was analyzed. The results showed that HUVECs exhibited orientation adhesion and growth with a certain direction after 6 days of culture. The 3D-controlled interconnected porous scaffolds with surface micropatterning then were used for the 3D culture of hMSCs. The hMSCs analysis showed a facilitating effect for cell distribution and growth in the 3D composite scaffolds compared to the control scaffold without interconnected porous structure and surface micropatterning.

権利情報:

• cc-by-nc-3.0
  

キーワード: surface micropatterning, interconnected porous structure, gelatin, nano-silica, PLGA, scaffold, bone tissue engineering

刊行年月日: 2025-08-12

出版者: Royal Society of Chemistry (RSC)

掲載誌:

• RSC Advances (ISSN: 20462069) vol. 15 issue. 35 p. 28581-28591

研究助成金:

• Japan Society for the Promotion of Science 24K03289

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1039/d5ra02891d

関連資料:

その他の識別子:

連絡先:

更新時刻: 2025-09-09 16:30:23 +0900

MDRでの公開時刻: 2025-09-09 16:18:45 +0900