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Research Highlights

Citation

Description:

One of the pathological mechanisms observed in neurodegenerative diseases in the central nervous system, including Alzheimer’s and Parkinson’s disease, is the accumulation of so-called microglia — cells that perform functions such as removing dead cells and excess synapses in the brain. When over-activated, microglia can also produce cytokines (small proteins) causing inflammation. Now, Mitsuhiro Ebara at the International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Japan, and colleagues have synthesized polymeric particles that can suppress microglial inflammation. These particles may be used in novel therapies for neurodegenerative diseases.

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• In Copyright
  

  In Copyright

Keyword: Inflammation, Alzheimer’s disease, Apoptosis, Phosphatidylserine, MPS

Date published: 2019-07-18

Publisher: National Institute for Materials Science

Journal:

• MANA E-BULLETIN vol. 52

Funding:

Manuscript type: Publisher's version (Version of record)

MDR DOI: https://doi.org/10.48505/nims.3792

First published URL: https://www.nims.go.jp/mana/research/highlights/vol52.html

Related item:

• refers
• (dataset)
• https://doi.org/10.1021/acsbiomaterials.8b01510

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Updated at: 2023-12-25 00:30:23 +0900

Published on MDR: 2022-12-16 13:59:28 +0900