International Center for Materials Nanoarchitectonics (WPI-MANA)
(National Institute for Materials Science)
説明:
(abstract)One of the pathological mechanisms observed in neurodegenerative diseases in the central nervous system, including Alzheimer’s and Parkinson’s disease, is the accumulation of so-called microglia — cells that perform functions such as removing dead cells and excess synapses in the brain. When over-activated, microglia can also produce cytokines (small proteins) causing inflammation. Now, Mitsuhiro Ebara at the International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Japan, and colleagues have synthesized polymeric particles that can suppress microglial inflammation. These particles may be used in novel therapies for neurodegenerative diseases.
権利情報:
In Copyright
キーワード: Inflammation, Alzheimer’s disease, Apoptosis, Phosphatidylserine, MPS
刊行年月日: 2019-07-18
出版者: National Institute for Materials Science
掲載誌:
研究助成金:
原稿種別: 出版者版 (Version of record)
MDR DOI: https://doi.org/10.48505/nims.3792
公開URL: https://www.nims.go.jp/mana/research/highlights/vol52.html
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更新時刻: 2023-12-25 00:30:23 +0900
MDRでの公開時刻: 2022-12-16 13:59:28 +0900
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[Vol. 52]Polymeric Particles with Anti-Inflammatory Potential for Neurodegenerative Disease Treatment_ WPI-MANA.pdf
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サイズ | 176KB | 詳細 |