Dong Hoon Shin
;
Sung Hyun Kim
;
Kush Coshic
;
Kenji Watanabe
(National Institute for Materials Science)
;
Takashi Taniguchi
(National Institute for Materials Science)
;
Gerard J. Verbiest
;
Sabina Caneva
;
Aleksei Aksimentiev
;
Peter G. Steeneken
;
Chirlmin Joo
Collection
Citation
Description:
(abstract)Accurate localization and delivery of biomolecules is pivotal for building tools to understand biology. The interactions of biomolecules with atomically flat 2D surfaces offer a means to realize both the localization and delivery, yet experimental utilization of such interactions has remained elusive. By combining single-molecule detection methods with computational approaches, we have comprehensively characterized the interactions of individual DNA molecules with hexagonal boron nitride (hBN) surfaces. Our experiments directly show that, upon binding to a hBN surface, a DNA molecule retains its ability to diffuse along the surface. Further, we show that the magnitude and direction of such diffusion can be controlled by the DNA length, the surface topography, and atomic defects. By fabricating a narrow hBN ribbon structure, we achieved pseudo-1D confinement, demonstrating its potential for nanofluidic guiding of biomolecules. Our work sets the stage for engineering 2D materials for high-throughput manipulation of single biomolecules and their applications in nanobiotechnology.
Rights:
Keyword: DNA diffusion , 2D material surfaces, hexagonal boron nitride (hBN)
Date published: 2025-06-17
Publisher: American Chemical Society (ACS)
Journal:
- ACS Nano (ISSN: 19360851) vol. 19 issue. 23 p. 21307-21318
Funding:
- Technische Universiteit Delft
- Ministry of Science and ICT, South Korea NRF-2023R1A2C2004745
- Ministry of Science and ICT, South Korea RS-2023-00261876
- H2020 Future and Emerging Technologies 881603
- Human Frontier Science Program RGP00026/2019
- Human Frontier Science Program RGP0047/2020
- H2020 European Research Council 101041486
- Ewha Womans University Frontier 10-10
- Division of Materials Research DMR-1827346
- Korea University
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek VI.C.202.015
- Kavli Institute of Nanoscience Delft
Manuscript type: Publisher's version (Version of record)
MDR DOI:
First published URL: https://doi.org/10.1021/acsnano.4c16277
Related item:
Other identifier(s):
Contact agent:
Updated at: 2026-02-17 08:30:14 +0900
Published on MDR: 2026-02-16 18:00:51 +0900
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