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説明:

Accurate localization and delivery of biomolecules is pivotal for building tools to understand biology. The interactions of biomolecules with atomically flat 2D surfaces offer a means to realize both the localization and delivery, yet experimental utilization of such interactions has remained elusive. By combining single-molecule detection methods with computational approaches, we have comprehensively characterized the interactions of individual DNA molecules with hexagonal boron nitride (hBN) surfaces. Our experiments directly show that, upon binding to a hBN surface, a DNA molecule retains its ability to diffuse along the surface. Further, we show that the magnitude and direction of such diffusion can be controlled by the DNA length, the surface topography, and atomic defects. By fabricating a narrow hBN ribbon structure, we achieved pseudo-1D confinement, demonstrating its potential for nanofluidic guiding of biomolecules. Our work sets the stage for engineering 2D materials for high-throughput manipulation of single biomolecules and their applications in nanobiotechnology.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: DNA diffusion
, 2D material surfaces, hexagonal boron nitride (hBN)


刊行年月日: 2025-06-17

出版者: American Chemical Society (ACS)

掲載誌:

• ACS Nano (ISSN: 19360851) vol. 19 issue. 23 p. 21307-21318

研究助成金:

• Technische Universiteit Delft
• Ministry of Science and ICT, South Korea NRF-2023R1A2C2004745
• Ministry of Science and ICT, South Korea RS-2023-00261876
• H2020 Future and Emerging Technologies 881603
• Human Frontier Science Program RGP00026/2019
• Human Frontier Science Program RGP0047/2020
• H2020 European Research Council 101041486
• Ewha Womans University Frontier 10-10
• Division of Materials Research DMR-1827346
• Korea University
• Nederlandse Organisatie voor Wetenschappelijk Onderzoek VI.C.202.015
• Kavli Institute of Nanoscience Delft

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1021/acsnano.4c16277

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更新時刻: 2026-02-17 08:30:14 +0900

MDRでの公開時刻: 2026-02-16 18:00:51 +0900